
Menafee was born in Talbotton, Georgia, in 1872. Her father was an African American carpenter and her mother was a Cherokee Indian. She was a graduate of Tuskegee University and after moving to South Carolina wanted to start a school modeled after her alma mater. Menafee traveled to nine different locations in the state before deciding to establish the school which is now Voorhees College on April 14, 1897. The school was founded above a store. She later raised funds for the school to purchase land outside of town. She died in 1906 at the age of 34 and is buried on the campus of Voorhees College.

